White matter thorn-shaped astrocytes associated with language dysfunction in Alzheimer’s disease

Takeaway

  • Strong correlation reported between language dysfunction in Alzheimer’s disease (AD) and astrocytic pathology.

Why this matters ?

    AD is associated with age-related tau pathology in astrocytes, yet the impact of white matter thorn-shaped astrocytes (WM-TSA) in modifying the clinical phenotype is unclear.