White matter lesions associated with rapid disease progression in early multiple sclerosis

Takeaway

  • Cerebellar lesion pattern is a key predictor of rapid clinical deterioration in people with early multiple sclerosis (MS).

Why this matters

    Although both gray and white matter are known to be affected early in the disease course of MS, it is unclear if this occurs randomly or follows a pattern that can predict early clinical disability. The findings may help identify people at risk of cortical atrophy and poor clinical outcome who could benefit from early treatment.