What mediates the association between diabetes and cognitive decline?

Takeaway

  • Lower cognition in older adults with diabetes was significantly associated with neurodegeneration, independently of small vessel disease (SVD) and Alzheimer’s disease (AD) pathology.

Why this matters

  • Type 2 diabetes has been associated with cognitive decline and dementia, with evidence suggesting that this is mediated by neurodegeneration and SVD.

  • Whether AD-specific pathology plays a mediating role in the association between diabetes and cognition has not been previously studied.