What can functional connectivity networks tell us about cognitive decline in Parkinson’s disease?

Takeaway

  • Longitudinal decline in resting-state functional connectivity (RSFC) can predict cognitive decline in Parkinson’s disease (PD) and precedes the onset of dementia.

Why this matters

  • Biomarkers for cognitive decline are urgently needed in PD as a large proportion of patients with PD will develop dementia.

  • PD disrupts functional connectivity in the brain but it is not known if the disruption is linked to dysfunctional proteins or if the changes occur before dementia.