Variation in PTEN-induced putative kinase 1 knockout rat model of Parkinson’s disease

Takeaway

  • The PTEN-induced putative kinase 1 (Pink1) knockout (Pink1-/-) rat model of Parkinson’s disease (PD) exhibits extreme variability, without consistent reductions in dopaminergic neurons at 8 months of age.

Why this matters

    Prior to using the Pink1-/- rat as an animal model for PD, individual labs should validate neural degeneration in their population, which may necessitate using animals at an older age.