Validation of dementia risk prediction models

Takeaway

  • Previously created risk prediction models for development of dementia based on demographics, hippocampal volume, and cerebrospinal fluid (CSF) markers were validated in multiple larger cohorts of people with mild cognitive impairment (MCI).

Why this matters

  • Half of people who experience MCI develop dementia in the course of 3 years; however, there are few diagnostic tools that can predict risk for developing dementia.

  • The many potential CSF and magnetic resonance imaging biomarkers in development may help to predict risk for dementia, ultimately leading to improvements in clinical outcomes.