Transcriptional analysis of glial cells in response to acute traumatic brain injury

Takeaway

  • Transforming growth factor ß (TGFß) and bone morphogenetic protein (BMP) act to regulate key processes for the repair of tissue injury and pro-inflammatory activity in activated astrocytes and microglia near the wound.

Why this matters

  • Traumatic brain injury affects more than 600 million individuals and represents a major public health issue.

  • TBI remains challenging to treat due to the induction of complex biomolecular pathways that are not fully understood.