The role of age and sex in apolipoprotein E ε4 associated longitudinal cognitive decline

Takeaway

  • The effect of apolipoprotein E (APOE)-ε4 status on cognitive decline over time is dependent on age and sex.

Why this matters

  • APOE-ε4 allele is a genetic risk factor for late-onset Alzheimer’s disease (AD) and associated with earlier onset of cognitive impairment although the role of age and sex in the effect APOE-ε4 related cognitive decline is not well understood.

  • Determining the role of age and sex on the effect that APOE-ε4 has on cognitive decline over time is crucial since APOE-ε4 has been used more and more to screen and identify individuals who may benefit from early interventions.