The relationship between disturbed sleep, β-amyloid deposition and cognitive impairment

Takeaway

  • Night-time sleep disturbance mediated the association between brain β-amyloid (Aβ) deposition and with cognitive performance in elderly people with cognitive impairment.

Why this matters

    In people with normal cognition, there is a known link between sleep, Aβ and brain function. However, in people with cognitive decline, this relationship is poorly understood.