The migraine risk allele increases susceptibility to chronic migraine and allodynia

Takeaway

  • Carriers of the migraine risk allele, TRPM8 rs10166942, have a predisposition to migraine chronification.

Why this matters

    This is the first study to demonstrate that the migraine risk allele, TRPM8 rs10166942, increases susceptibility to migraine chronification. Further investigation into the role of TRPM8 in allodynia pathogenesis and migraine chronification could lead to novel treatments.