Subcortical axonal arousal network injury leads to coma

Takeaway

  • Initial evidence demonstrates the reduced integrity of the ascending arousal network (AAn) axonal pathways in post-acute traumatic disorders of consciousness.

Why this matters

    Induction of coma in patients who have undergone acute severe traumatic brain injury (TBI) is thought to be caused by axonal injury to the AAn pathways and initial in vivo study evidence supports reduction in AAn connectivity.