Study uncovers a novel regulatory role for neuregulin-1 beta 1 early in the disease course in multiple sclerosis and experimental autoimmune encephalomyelitis

Abstract

Multiple sclerosis is characterized by immune mediated neurodegeneration that results in progressive, life-long neurological and cognitive impairments. Yet, the endogenous mechanisms underlying multiple sclerosis pathophysiology are not fully understood. Here, we provide compelling evidence that associates dysregulation of neuregulin-1 beta 1 (Nrg-1β1) with multiple sclerosis pathogenesis and progression.