Reducing risk of disabling stroke with ticagrelor after an ischemic stroke


  • Compared with aspirin alone, the addition of ticagrelor significantly reduced the 30-day risk of disabling stroke or death in patients who had a noncardioembolic acute ischemic stroke.

Why this matters

  • Disability 3 months after stroke onset has been reported to be an independent predictor of future death. Disability after a transient ischemic attack (TIA) or ischemic stroke may be caused by damage from the index stroke or a subsequent stroke.

  • Reducing subsequent disabling stroke is the main goal of preventative treatment in the acute setting after TIA or ischemic stroke.

  • Ticagrelor was able to prevent disabling stroke or death at 30 days and reduce the total burden of disability in patients with TIA or minor ischemic stroke, thus may be a useful therapy for improving long-term outcomes following TIA or ischemic stroke.

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