Prognosis following gamma knife radiosurgery for brain metastases in renal cell carcinoma

Takeaway

  • The updated Renal Prognostic Graded Assessment (GPA) is a valid instrument for estimating survival in patients with renal cell carcinoma and brain metastases who have been treated with gamma knife radiosurgery (GKRS).

Why this matters

  • Between 8–28% of people with renal cell carcinoma develop brain metastases. The incidence of brain metastasis has been growing in this population as detection methods become more sensitive and systemic treatments extend survival.

  • The Renal GPA is a widely used risk score for estimating survival in patients with renal cell carcinoma and brain metastases. The score was recently updated based on data from a heterogeneously-treated cohort from 2006–2015. However, the updated score has not been sufficiently validated in patients treated with GKRS.