Prenatal lipopolysaccharide exposure triggers behavioral and neuropathological changes

Takeaway

  • Bacterial infection caused by lipopolysaccharide (LPS) exposure during the prenatal phase in CD-1 mice triggers Alzheimer’s disease (AD)-related changes in behavior and neuropathology in offspring.

Why this matters

    Bacterial infections are common in women of a reproductive age. Recent evidence suggests that activation of the maternal immune system may facilitate the development of AD. Understanding the effects of maternal immune activation on the pathogenesis of AD is necessary for the development of future treatments.