Predicting fast decline in patients with Alzheimer’s disease

Takeaway

  • A model combining plasma levels of neurofilament light chain (NfL) and scores of two cognitive tests could reliably predict fast decline in patients with Alzheimer’s disease (AD).

Why this matters

  • Faster disease progression in patients with AD is associated with higher risks of mortality, autonomy loss, and institutionalization.

  • Accelerated decline occurs in approximately 30% of patients, but it is currently unclear which disease and/or patient variables are associated with this phenomenon.