Oculomotor and nonmotor abnormalities in late-onset GM2 gangliosidosis

Takeaway

  • Late-onset GM2 gangliosidosis (LOGG) is associated with oculomotor dysfunction, as well as cognitive/neuropsychiatric symptoms and sleep problems.

Why this matters

  • LOGG is a very rare, difficult to diagnose, neurodegenerative lysosomal storage disorder caused by a deficiency in β-hexosaminidase A and/or B.

  • Oculomotor abnormalities may be a predictor of disease severity in people with LOGG and an early sign of developing motor disease.