Novel genes associated with intracranial hemorrhage risk

Takeaway

  • Novel loci at 2q33 and 13q34 associated with non-lobar intracranial hemorrhage (ICH) and genes at these loci have been previously implicated with common diseases or traits related to cerebral small vessel disease (CSVD) and are now implicated in ICH.

Why this matters

    ICH and small vessel ischemic stroke (SVS) are the most acute manifestations of CSVD and beyond managing hypertension there are no effective or established preventative approaches to reduce its risk. However, a combined genome-wide association study (GWAS) that correlates these two diseases may lead to the detection of novel genetic factors for CSVD and possibly lead to the development of novel effective prevention strategies.