Neuromuscular junction transmission in people with mitochondrial disease

Takeaway

  • Neuromuscular junction (NMJ) abnormalities are common in people with mitochondrial disease and is independent of coexisting neuropathy and myopathy.

Why this matters

  • These findings suggest specific involvement of the NMJ in people with mitochondrial disease.

  • Modulators of neuromuscular transmission may offer therapeutic benefit in some people with mitochondrial disease.