Microglia and Huntington’s disease pathogenesis

Takeaway

  • Microglial elimination in a Huntington’s disease (HD) mouse model prevented disease related grip strength deficits, object memory deficits, and perineuronal net loss.

Why this matters

    This study implicates microglia as a regulator of perineuronal net formation and further characterizes the role of microglial accumulation in HD pathogenesis.