Metabolic profile and language impairment in corticobasal syndrome and progressive supranuclear palsy

Takeaway

  • People with corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP) have differing levels of language impairment, but in both groups nonfluent variant of primary progressive aphasia (nfv-PPA) was associated with a left-side hypometabolic pattern while lack of language impairment was associated with right hemisphere involvement.

Why this matters

    Better characterization of CBS and PSP is needed in terms of imaging markers to aid physicians in the clinical setting: fluorodeoxyglucose positron emission tomography (FDG-PET) combined with other biomarkers may help clarify the relationship between symptoms and underlying pathology.