Takeaway
The leucine zipper 4 (LUZP4) antigen is a potential serological biomarker of germ-cell tumors and associated paraneoplastic neurological syndrome (PNS).
Why this matters
The use of LUZP4 as a serological biomarker in PNS may be a useful tool to assist in detecting underlying cancer pathology in those with occult tumors with paraneoplastic neurological presentations.