Investigation of plasma soluble CD14 as a biomarker for dementia

Takeaway

  • In 2 large cohort studies, the inflammatory marker plasma soluble CD14 (sCD14) correlated with risk of dementia, with a 12% increase in the risk of incident dementia for every standard deviation increase in sCD14.

Why this matters

    These results indicate the sCD14 may be a suitable non-invasive biomarker for incident dementia and related endophenotypes, to enhance current imaging and cerebrospinal fluid markers.