Investigating safety outcomes with early mobilization of stroke patients

Takeaway

  • Very early mobilization of stroke patients is associated with increased risk of mortality 14-days post-stroke.

Why this matters

  • It is unclear as to the risk-benefit profile of early mobilization following stroke.

  • A Very Early Rehabilitation Trial (AVERT) was a randomized trial which investigated the difference in serious adverse event (SAE) outcomes between a very early mobilization protocol (VEM) which included a higher amount, frequency and intensity of out-of-bed, task-specific training of sitting, standing and walking as compared to usual standard of care (UC).

  • The primary safety endpoints for AVERT were read-out at 3 months post-stroke; however, a prespecified analysis was also planned for a 14-day analysis, the results of which are reported here.

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