Expression of ecotropic viral integration site-1 (EVI1) and epidermal growth factor receptor (EGFR) are correlated in A172 and YKG1 glioblastoma multiforme (GBM) cells. EVI1 regulates EGFR transcription and EVI1 knockdown suppresses the proliferation of GBM cells.
Why this matters
EVI1 transcription factor contributes to poor prognosis of cancer and plays a role in the regulation of epidermal growth factor receptor (EGFR) transcription.
Understanding the role of EVI1 in glioblastoma cells is important for identifying potential new targets for therapeutic development.