Going it alone: Does tau associate with apolipoprotein E ε4 independent of amyloid-β?

Takeaway

  • Tau pathology occurs in carriers of apolipoprotein E ε4 (APOEε4) and is independent of
    amyloid-β involvement.

Why this matters

    APOEε4 is a well-established genetic risk factor for Alzheimer’s disease (AD) that causes amyloid-β deposition, but its association with cerebral tau pathology is unclear.