Glyoxalase-1 levels are altered in amyotrophic lateral sclerosis patient-derived astrocytes

Takeaway

  • Loss of metabolic flexibility, involving adenosine, fructose and glycogen metabolism defects, as well as disrupted energy substrate transport, contributed to increased sensitivity to starvation-induced stress and reduced cell survival in C9orf72 induced astrocytes.

  • There is a reduction in the levels of methylglyoxal removing enzyme, glyoxalase-1 (GLO1) in familial and sporadic cases of amyotrophic lateral sclerosis (ALS), in addition to sporadic cases of Parkinson’s disease.

Why this matters

  • Therapeutic manipulation of disrupted metabolic pathways could potentially ameliorate disease progression in ALS and Parkinson’s disease.