Functional connectivity changes in dementia with Lewy bodies

Takeaway

  • Alzheimer’s disease (AD)-like changes in default mode network (DMN) connectivity were observed in patients with dementia with Lewy bodies (DLB) who had a higher burden of AD co-pathology, and the pattern of tau distribution was associated with the brain’s functional network structure.

Why this matters

  • DLB is typically defined by the presence of Lewy bodies. However, many cases also exhibit AD pathology, which is associated with a more rapid cognitive decline.

  • Functional connectivity studies of AD have shown decreased connectivity of the DMN, but it is unclear how this network is affected in DLB.