Dopamine transporter imaging and clinical phenotype of LRRK2 and GBA mutation non-manifest carriers

Takeaway

  • Subtle motor and non-motor symptoms of Parkinson’s disease (PD) are present in non-manifesting carriers with LRRK2 and GBA mutations, which emerge prior to deficiencies in dopamine transporters (DATs).

Why this matters

    This study indicates that during prodromal PD, LRRK2 and GBA mutations accompanied by early motor and non-motor symptoms, may help predict those at risk of developing motor PD.