Developing a biomarker signature for multiple sclerosis phenotypes

Takeaway

  • The long noncoding RNA (LncRNA) transcripts ENSG00000260302, ENSG00000270972, ENSG00000272512 and ENSG00000223387 are expressed at higher levels in people with multiple sclerosis (MS) and a severe phenotype versus those with MS and a mild phenotype.

Why this matters

    No prognostic biomarkers exist to identify people with MS who might suffer a more aggressive disease course and benefit from intensive therapy, and the identified lncRNAs show promise in this regard.