Correlation between C99 levels and cognitive decline in Alzheimer’s disease

Takeaway

  • A new method to detect amyloid precursor protein (APP) metabolites indicates that C99, rather than amyloid-β (Aβ), is responsible for nerve cell degeneration and death in Alzheimer’s disease (AD).

Why this matters

  • Because the distribution of Aβ deposits in brains of patients with AD has a poor correlation with dementia severity, it is thought that APP metabolites other than Aβ may have a role in AD pathophysiology.

  • Knowledge of the distribution and levels of APP metabolites in specific cells and tissues may lead to new treatments for AD and better understanding of treatments in development.