Biomarkers for differential diagnosis of atypical Parkinsonian syndromes and Parkinson’s disease

Takeaway

  • Measures of cognition, cerebrospinal fluid analysis and several other disease biomarkers, can differentiate Parkinson’s disease (PD) from atypical parkinsonisms and distinguish progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) subtypes with high diagnostic accuracy.

Why this matters

    This survey of distinguishing characteristics identify biomarkers that may enhance early differential diagnosis of PSP and CBS from PD to better tailor treatments and select participants for clinical trials.