APOE ɛ4 links white matter hyperintensities and poor cognition in dementia

Takeaway

  • APOE ɛ4 mediates the link between white matter hyperintensities (WMH) and cognitive performance in people with Alzheimer disease (AD) and dementia with Lewy bodies (DLB).

Why this matters

  • Information about APOE ɛ4 status may be useful to understand the relative contributions of different pathologies to an individual’s unique dementia syndrome, and to guide therapy.