Alzheimer’s disease and microRNAs

Takeaway

  • microRNA (miRNA) expression data across three specimens in Alzheimer’s disease (AD) cases versus controls identifies unique miRNAs with study-wide significant differential expression.

Why this matters

    miRNA may have the ability to affect the underlying pathogenic pathway of AD and prove to be potential biomarkers; thus, by identifying specific miRNAs that demonstrate a significant and consistent differential expression in AD versus healthy controls, a knowledge base may be generated that could lead to future investigations aimed at identifying miRNA signatures able to differentiate between healthy aging and AD, potentially in the prodromal stage.