Altered connectivity and cognitive performance in relapsing remitting multiple sclerosis

Takeaway

  • These results suggest that cognitive performance, even in patients with relapsing remitting multiple sclerosis (RRMS) and very mild disability, may reflect loss of structural connectivity.

Why this matters

  • Magnetic resonance imaging (MRI) is currently the best available biomarker to track MS pathophysiology, but conventional MRI metrics are poorly correlated with clinical symptoms.

  • The network mapping method utilized in this study provides new insights into the pathophysiological network changes underlying MS.