Altered brain insulin signaling is associated with cognitive performance and Alzheimer’s disease

Takeaway

  • A critical node of insulin signaling in the brain, serine/threonine-protein kinase (AKT), was found to be related to Alzheimer’s disease (AD) pathology and proximate-to-death cognitive performance in older people.

Why this matters

    These findings support further research into clinically relevant targets such as how nutrition may influence insulin signaling and therefore cognition and AD.

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