ALS phenotype is influenced by age, sex, and genetics

Takeaway

  • Age, sex and gene variants are correlated with different motor and cognitive phenotypes of amyloid lateral sclerosis (ALS).

Why this matters

  • ALS is a neurodegenerative disease that is complex due to the heterogeneity of its phenotype, which has both motor and cognitive components.

  • The identification of factors that modify ALS phenotype may help to reclassify patients into more pathogenically meaningful subgroups for targeted personalized therapy.