A TP53 mutation leads to gain-of-function phenotypes in multifocal glioblastoma

Takeaway

  • A man with multifocal glioblastoma acquires an aggressive secondary tumor with a gain-of-function TP53 mutation that leads to progressive and invasive malignancy.

Why this matters

    This unique case report reveals the complexity of multifocal glioblastomas. The observed tumor-specific features highlight the importance of genomic profiling; characterizing each tumor individually could assist the development of personalized treatment plans through molecularly targeted therapy.

Vuoi saperne di più?

Accedi o registrati per accedere a tutti i contenuti di Neurodiem.

Hai già un account? Accedi

International Medical Press is a global provider of independent medical education. Its mission is to provide healthcare professionals with high-quality, trusted medical information with the aim of helping optimize patient care.

No responsibility is assumed by International Medical Press for any injury and/or damage to persons or property through negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Because of rapid advances in the medical sciences, International Medical Press recommends that independent verification of diagnoses and drug dosages should be made. The opinions expressed do not reflect those of International Medical Press or the sponsor. International Medical Press assumes no liability for any material contained herein.